COVID-Zero: The Exit Strategy

Written by: Mark Henderson. Photography by: Louis reed

The impact of COVID-19 has been unlike anything any of us have experienced before, but the secondary impacts and the lockdowns in place to contain it are equally catastrophic and, in some cases, deadly. In April, the Wellcome Trust launched their plan for an exit strategy – COVID-Zero – alongside a fund that will invest in treatments, vaccines, and testing for coronavirus. Welcome’s Mark Henderson explains why the only way out of the pandemic is science and urges businesses to join the coalition to put an end to the threat entirely.

Just as coronavirus was starting out on its breakneck journey around the world in January, Global leaders gathered for the World Economic Forum’s annual meeting in Davos. 

The buzz phrase this year was unmistakable: ‘stakeholder capitalism’. The idea that business has goals beyond profit or shareholder value, that it really exists to create shared social goods that benefit the wider world, seemed to come up in almost every panel and conversation. 

To critics, this notion was a luxury of the long bull market. Just wait for a market correction, they argued, and we would see whether talk of social purpose as a new bottom line would hold up.

That test has come more swiftly than most anticipated, as nations have plunged their economies into deliberate recessions to contain the spread of COVID-19. Amid lockdowns and furloughs, few business models have not been turned upside down. Companies of all sizes are struggling to survive. 

Many are living up to ideals forged in a more benign economic climate, by protecting jobs and continuing to pay suppliers. Others have turned to producing goods for which society has suddenly acquired a greater need: Burberry is making surgical gowns, and LMVH hand sanitiser. 

Business feels, with good reason, that it is doing its bit to manage this crisis. But business and investment leaders are missing an even greater opportunity to demonstrate the social value they create. They should do their bit to resolve it too.

They should do this by helping to finance research into vaccines, treatments, and testing, without which there can be no true exit from this pandemic. Science is the only route to COVID-Zero – no preventable deaths, no further lockdowns, no more disruption. 

The physical distancing that countries all over the world are implementing to suppress COVID-19 is so disruptive that it is tempting to think it must be a solution. It’ll get more tempting still as outbreaks peak and economies start tentatively to open up. Yet critical as lockdowns are, they will not bring the world closure. 

Until we have vaccines to stop transmission in its tracks, treatments to save lives and stop the sick needing intensive care, and better testing that can identify cases on a massive scale, it will be difficult if not impossible to get back to business as usual. As the distancing measure is eased, we can expect further epidemic waves and further business-destroying interventions to beat them back.

Science is moving at unprecedented speed to develop different interventions that will allow us to move on. More than 60 vaccine projects are underway. A COVID-19 Therapeutics Accelerator is rapidly evaluating existing drugs for effectiveness against the virus. Plans are afoot to scale up manufacture of vaccines and treatments now, before we know whether or not they work, so the world can rapidly make the billions of doses we will need when we get positive results. 

All this work, though, is well short of the funding it needs. The Global Preparedness Monitoring Board, an expert group convened by the WHO and the World Bank, estimates that an initial $8bn is needed right now so that all the necessary R&D can get started. Tens of billions more will be needed over the coming year, to produce and procure the new medicines as soon as they’re developed. 

Much of this funding will have to come from sovereign governments, and the European Commission is galvanising donors through a virtual pledging conference on May 4.

At Wellcome, we are also inviting corporations and investment funds, as well as individual business leaders with the personal resources for philanthropy, to donate to this society-wide effort through a new initiative called COVID-Zero. 

It is their opportunity to advance the science without which their business models face indefinite disruption.

Since we launched COVID-Zero, we’ve opened discussions with business donors keen to invest millions of dollars. Mastercard and Citadel are among those who have already stepped up. Many others have wished us well, but say they are focusing their philanthropy on hardship in their local or professional communities. This is an important and noble way for businesses to deliver social value. They will serve their communities still better by matching these donations with support for the vaccine, treatment, and testing research that will remove the threat, not just keep it at bay.

The money they put in will go directly to efforts to find drugs and improve tests, to CEPI, the organisation founded at Davos three years ago to develop vaccines against epidemic threats, and to the WHO, which plays a critical part in coordinating this work and needs more resources, not politically-motivated cuts. There are few better investments any business can make today.

Those with the vision and imagination to finance this research will be able to say to their employees, to their customers, to their communities, that they did more than treat all their stakeholders well during the greatest global crisis since 1945. 

They will also be able to say that they were a critical part of the solution.


Mark Henderson

Mark Henderson is Director of Communications at the Wellcome Trust, the world’s second highest-spending charitable foundation, and a member of its Executive Leadership Team. He leads all aspects of communications, with a particular focus on building and sustaining Wellcome’s reputation and influence. Before joining Wellcome, Mark had a 15-year career in journalism at The Times of London, where he was Science Editor and won several awards for his reporting. He has written two books: The Geek Manifesto: Why Science Matters, which explores the relationship between science and politics, and 50 Genetics Ideas You Really Need to Know. He is an avid skier and cricket fan, and tweets at @markgfh.

To get involved with COVID-Zero, please email: covidzero@wellcome.ac.uk.

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